Antidepressant Medications Anti-depressant Drugs Antidepressant: fluoxetine, Prozac, Veritina, Eufor, Deprax, Psiquial
Antidepressant: fluoxetine, Prozac, Veritina, Eufor, Deprax, Psiquial
Generic Name: fluoxetine
Brand Name(s): Prozac, Veritina, Eufor, Deprax, Psiquial
Common Use: Antidepressant
Anti-OCD
Antipanic
Antidepressant - Antiobsessional - Antibulimic
The antidepressant, antiobsessional, and
antibulimic actions of fluoxetine are presumed to be linked
to its ability to inhibit the neuronal reuptake of serotonin.
Similarly because of the long half-lives of
fluoxetine and norfluoxetine, it may take up to 1 to 2 months
for the active drug substance to disappear from the body.
This is of potential consequence in withdrawal of fluoxetine.
Depression:
For the symptomatic relief of depressive illness.
Bulimia Nervosa:
Fluoxetine has been shown to significantly decrease binge-eating
and purging activity when compared with placebo treatment.
Obsessive Compulsive Disorder:
Fluoxetine has been shown to significantly reduce the symptoms
of obsessive-compulsive disorder in double-blind, placebo-controlled
clinical trials.
The obsessions or compulsions must be experienced
as intrusive, markedly distressing, time-consuming, or interfering
significantly with the person's social or occupational functioning.
There have been reports of serious reactions
in patients receiving fluoxetine in combination with a MAO
inhibitor and in patients who have recently discontinued
fluoxetine and then started on a MAO inhibitor.
Adverse Side Effects
In clinical trials, the most commonly observed
adverse events associated with the use of fluoxetine and
not seen at an equivalent incidence among placebo treated
patients were: CNS complaints, including headache, nervousness,
insomnia, drowsiness, fatigue or asthenia, anxiety, tremor,
and dizziness or lightheadedness; gastrointestinal complaints,
including nausea, diarrhea, dry mouth and anorexia; and
excessive sweating.
The more common events causing discontinuation
included: Psychiatric, primarily nervousness, anxiety, and
insomnia; digestive, primarily nausea; nervous system, primarily
dizziness, asthenia and headaches; skin, primarily rash
and pruritus. In obsessive compulsive disorder studies,
12.1% of fluoxetine treated patients discontinued treatment
early because of adverse events. Anxiety, and rash, at incidences
of less than 2%, were the most frequently reported events.
In bulimia nervosa studies, 10.2% of fluoxetine treated
patients discontinued treatment early because of adverse
events. Insomnia, anxiety and rash, at incidences of less
than 2%, were the most frequently reported events.
Overdose
Nausea and vomiting were prominent in overdoses
involving higher fluoxetine doses. Other prominent symptoms
of overdose included agitation, restlessness, hypomania,
and other signs of CNS excitation, including seizures.
Establish and maintain an airway; ensure
adequate oxygenation and ventilation. Activated charcoal,
which may be used with sorbitol, may be as or more effective
than emesis or lavage, and should be considered in treating
overdose.
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