Antidepressant Medications Anti-depressant Drugs Antidepressant: sertraline, Zoloft, Sercerin, Tolrest, Lustral, Altruline

Antidepressant: sertraline, Zoloft, Sercerin, Tolrest, Lustral, Altruline

Generic Name: sertraline
Brand Name(s): Zoloft, Sercerin, Tolrest, Lustral, Altruline
Common Use: Antidepressant

For the symptomatic relief of depressive illness. However, the antidepressant action of sertraline in hospitalized depressed patients has not been adequately studied.

Contraindications are Patients with known hypersensitivity to the drug.

No clinical data are available on the effects of the combined use of sertraline and MAO inhibitors; therefore, sertraline should not be administered together with MAO inhibitors. At least 14 days should elapse between the discontinuation of an MAO inhibitor and the initiation of treatment with sertraline, as well as between the discontinuation of sertraline and the initiation of treatment with an MAO inhibitor. Administration at shorter intervals may increase the risk of serious events.

Adverse Side Effects

The most commonly observed adverse events associated with the use of sertraline were:

gastrointestinal complaints, including nausea, diarrhea/loose stools and dyspepsia; male sexual dysfunction (primarily ejaculatory delay); insomnia and somnolence; tremor; increased sweating and dry mouth; and dizziness.

The more common events associated with discontinuation included agitation, insomnia, male sexual dysfunction (primarily ejaculatory delay), somnolence, dizziness, headache, tremor, anorexia, diarrhea/loose stools, nausea and fatigue.

Infrequent:

Flushing, mydriasis, increased saliva, cold clammy skin. Confusion.weight decrease, weight increase.Abnormal dreams, aggressive reaction, amnesia, apathy, delusion, depersonalization, depression, aggravated depression, emotional lability, euphoria, hallucination, neurosis, paranoid reaction, suicide attempt (including suicidal ideation), teeth-grinding, abnormal thinking. intermenstrual bleeding,

Infrequent: Postural dizziness, hypertension, hypotension, postural hypotension, edema, dependent edema, periorbital edema, peripheral edema, peripheral ischemia, syncope, tachycardia.Ataxia, abnormal coordination, abnormal gait, hyperesthesia, hyperkinesia, hypokinesia, migraine, nystagmus, vertigo. Acne, alopecia, pruritus, erythematous rash, maculopapular rash, dry skin. muscle cramps, muscle weakness, urinary retention.

Rare: Pallor. Precordial chest pain, substernal chest pain, aggravated hypertension, myocardial infarction, varicose veins. Local anesthesia, coma, convulsions, dyskinesia, dysphonia, hyporeflexia, hypotonia, ptosis.Bullous eruption, dermatitis, erythema multiforme, abnormal hair texture, hypertrichosis, photosensitivity reaction, follicular rash, skin discoloration, abnormal skin odor, urticaria. breast enlargement , female breast pain , leukorrhea , menorrhagia , atrophic vaginitis .

Overdose

There are no specific antidotes for sertraline. In managing overdose, the possibility of multiple drug involvement must be considered. Establish and maintain an airway, insure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be considered in treating overdose.

BACK TO THE LIST